High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis.

Kolijn PMM, Saberi Hosnijeh F, Späth F, Hengeveld PJ, Agathangelidis A, Saleh M, Casabonne D, Benavente Y, Jerkeman M, Agudo A, Barricarte A, Besson C, Sánchez MJ, Chirlaque MD, Masala G, Sacerdote C, Grioni S, Schluze M, Nieters A, Engelfriet P, Hultdin M, McKay JD, Vermeulen RCH, Langerak AW.

Blood 2022; 139: 1557-1563. doi: 10.1182/blood.2021012890. PMID: 34662377

https://pubmed.ncbi.nlm.nih.gov/34662377